North & North · Research
What the three letters actually change
Your blood is full of albumin, a protein your body is in no hurry to get rid of. DAC, short for Drug Affinity Complex, is a small attachment that lets a peptide grab onto it and stick around for days. No DAC means no attachment, and no ride.
What the attachment does
The peptide does not last longer because it is tougher. It lasts longer because it holds onto something that already does.
Albumin is the most common protein in your blood, and your body is in no rush to clear it out. The drug affinity complex is the hook that fastens a peptide to it, so the compound goes wherever albumin goes and stays as long as albumin stays. Take the hook off and there is nothing holding it there. It gets cleared on its own terms, which are a great deal quicker. That is the whole trick, and it is why two products with almost the same name behave nothing alike.
Side by side
| Comparison point | With DAC | No DAC |
|---|---|---|
| What the letters mean | Drug Affinity Complex. An addition built onto the peptide. | The same peptide without that addition. |
| What it holds onto | Albumin, a protein already circulating in your blood. | Nothing. It travels alone. |
| How long it persists | Long acting. Albumin carries it, so it stays in circulation. | Short acting. It follows the body’s own rhythm. |
| Other names for it | CJC-1295 DAC, CJC-1295 with DAC. | Mod GRF 1-29, Modified GRF (1-29), CJC-1295 No DAC. |
| What North & North supplies | Not offered. | Research material only, 10mg, >99% purity. |
Where the confusion starts
The short acting one
You will see it as CJC-1295 No DAC, Mod GRF 1-29, or Modified GRF (1-29). All three are the same 29 amino acid compound. The CJC-1295 name stuck to it through habit rather than chemistry, and that is where most of the confusion in this category begins.
The long acting one
Sold as CJC-1295 DAC, or CJC-1295 with DAC. This is the one the 2006 study measured. If a source just says CJC-1295 and leaves it there, it usually means this version, and it tells you nothing about the other.
Current work
The interesting part is the receptor. Both forms bind the same one the body’s own signal uses, which is why research describes them as working inside the feedback loop already running rather than overriding it. That is a genuinely different thing to study than supplying the hormone itself, and it is where the current attention sits.
Three 2026 reviews map this family of compounds: one on the growth hormone axis specifically, one on peptides in sports medicine, and one placing peptides in the wider picture of healthy aging. All three are recent, peer reviewed, and linked below to read in full rather than summarised into a claim.
The short action is the reason the No DAC form is studied on its own terms. Following the body’s own rhythm is a different research question from holding levels steady for days, so published work names which form it used, and so does this page. The 2006 paper below is the foundational human study of the long acting DAC form, kept here because it is where this compound family enters the human literature. Every source was opened and read before it was cited.
Common questions
It means the peptide travels on its own. DAC is an attachment that binds to albumin and keeps a compound circulating for days. Without it the peptide is short acting and follows the body’s own rhythm, which is exactly why it is studied as its own subject.
Duration. The DAC version binds albumin and stays in circulation for days. The No DAC version is short acting and works with the body’s own rhythm. Two different research questions, which is why published work names which form it used.
Same compound, three names. Mod GRF 1-29, Modified GRF (1-29) and CJC-1295 No DAC all point at the same thing. Suppliers and papers use whichever they prefer, which is why this is the single most confusing corner of the category.
Because duration changes what a study can look at. Work on the long acting DAC form asks what happens when levels stay up; work on the short acting No DAC form asks what happens when the signal follows the body’s own rhythm. Recent reviews from 2026 cover both.
Because each form has its own body of work. A source that names which version it studied is telling you which question it answered, and that is what makes it useful. It is the first thing worth checking.
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The statements made on this website have not been evaluated by the U.S. Food and Drug Administration. Products offered through this website and information presented here are not intended to diagnose, treat, cure, or prevent any disease or medical condition. North & North LLC is not a pharmacy, compounding pharmacy, compounding facility, medical provider, or outsourcing facility. All products are sold strictly for research, laboratory, or analytical purposes only and are not intended for human consumption. Customers are solely responsible for compliance with all applicable federal, state, and local laws governing the purchase, possession, handling, and use of research-use compounds.
